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Structural Biology

Structural Biology aims to solve the 3D structure of biological macromolecules from proteins, to nucleotides, to ligands. Depending on the modality the resolution can be better than 1 Å. The highest resolution can usually be achieved by macromolecular X-ray crystallography (MX) followed by Cryo Electron Microscopy. Other modalities used for structural biology include Nuclear Magnetic Resonance Spectroscopy (NMR) or Small Angle Scattering (SAXS).

IMAGED OBJECTS
atoms, molecules, proteins, nucleotides, ligands
Structural Biology Image
CryoEM reconstruction of helical p62/SQSTM1 autophagy cargo protein
©Helmholtz Imaging, Daniel Mann (FZJ)

Structural Biology in Helmholtz Imaging CONNECT:

Modality
Nuclear magnetic resonance spectroscopy (NMR)

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique based on re-orientation of atomic nuclei with non-zero nuclear spins in an external magnetic field. This …

HZI - NMR-Based Structural Chemistry

HZDR on NMR

HIPS Technology Plattform

Biomolecular NMR Centre - FZJ

Bavarian NMR Center

Experimental methods at HZDR Department of Biogeochemistry

In Helmholtz Imaging CONNECT
➤Applications: 3 ➤Facilities: 4 ➤Centers: 7 ➤Instruments: 6 ➤Labs: 6 ➤Experts: 3 ➤Solutions: 0
Modality
Rotation crystallography

Rotation crystallography is a way to acquire diffraction data from a single crystal sample. The crystal is mounted on a goniometer system, and a series of diffraction patterns are acquired while rotating the crystal. The …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 1 ➤Centers: 1 ➤Instruments: 1 ➤Labs: 0 ➤Experts: 3 ➤Solutions: 0
Modality
Serial crystallography (SX)

Serial crystallography is a method for making diffraction measurements from crystals. A series of crystals are delivered into the path of the X-ray beam (by a liquid jet, tape drive or other system), and a …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 2 ➤Centers: 1 ➤Instruments: 1 ➤Labs: 0 ➤Experts: 2 ➤Solutions: 1
Modality
Small Angle X-ray Scattering - SAXS

With SAXS structural and dynamic properties of soft matter can be studied. This allows the measurement of shape, size and oligomeric states of samples in solution, pf pastes powders and films. Applications of SAXS can …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 3 ➤Centers: 8 ➤Instruments: 2 ➤Labs: 0 ➤Experts: 5 ➤Solutions: 0
Modality
X-ray Crystallography

X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 1 ➤Centers: 1 ➤Instruments: 2 ➤Labs: 0 ➤Experts: 3 ➤Solutions: 0
Facility
European XFEL (EuXFEL)

The 3.4 km long European XFEL generates extremely intense X-ray flashes used by researchers from all over the world. The flashes are produced in underground tunnels and allow scientists to map atomic details of viruses, …

In Helmholtz Imaging CONNECT
➤Applications: 3 ➤Centers: 1 ➤Instruments: 3 ➤Labs: 2 ➤Modalities: 6 ➤Experts: 4 ➤Solutions: 1
Facility
PETRA III

DESY operates one of the world's brightest storage-ring-based X-ray radiation sources: PETRA III offers scientists outstanding opportunities for experiments with X-rays of exceptionally high brilliance. This particularly benefits researchers investigating very small samples or requiring …

In Helmholtz Imaging CONNECT
➤Applications: 5 ➤Centers: 2 ➤Instruments: 11 ➤Labs: 2 ➤Modalities: 31 ➤Experts: 16 ➤Solutions: 1
Center
Deutsches Elektronen-Synchrotron (DESY)

DESY is one of the world’s leading accelerator centres. Researchers use the large-scale facilities at DESY to explore the microcosm in all its variety – from the interactions of tiny elementary particles and the behaviour …

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➤Applications: 152 ➤Facilities: 4 ➤Instruments: 21 ➤Labs: 85 ➤Modalities: 237 ➤Experts: 26 ➤Solutions: 2
Center
Forschungszentrum Jülich (FZJ)

Forschungszentrum Jülich is a large-scale national research facility in the Helmholtz Association of German Research Centres. By conducting research on the global challenges currently facing society, we contribute to the welfare of mankind and responsible …

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➤Applications: 25 ➤Facilities: 2 ➤Instruments: 22 ➤Labs: 8 ➤Modalities: 47 ➤Experts: 14 ➤Solutions: 3
Center
Helmholtz-Zentrum Berlin für Materialien und Energie (HZB)

Materials for a sustainable energy supply and operation of the electron storage ring BESSY II – those are the cornerstones of HZB and its research. Both of these fields complement each other, since questions arising …

In Helmholtz Imaging CONNECT
➤Applications: 6 ➤Facilities: 2 ➤Instruments: 0 ➤Labs: 1 ➤Modalities: 22 ➤Experts: 3 ➤Solutions: 0
Center
Karlsruher Institut für Technologie (KIT)

KIT is 'The Research University in the Helmholtz Association.' As one of the biggest science institutions in Europe, the only German University of Excellence with national large-scale research facilities combines a long university tradition with …

In Helmholtz Imaging CONNECT
➤Applications: 17 ➤Facilities: 6 ➤Instruments: 32 ➤Labs: 6 ➤Modalities: 53 ➤Experts: 16 ➤Solutions: 4
Instrument
P11 High-throughput Macromolecular Crystallography Beamline @ PETRA III

The High-throughput Macromolecular Crystallography beamline P11 at PETRA III is dedicated to diffraction experiments of biological macromolecules. The beamline is designed to provide a stable yet flexible setup ideally suited for experiments in conventional rotation …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 1 ➤Centers: 1 ➤Labs: 0 ➤Modalities: 3 ➤Experts: 2 ➤Solutions: 1
No lab found.
Solution
CrystFEL

CrystFEL is a suite of programs for processing serial crystallography data. CrystFEL comprises programs for indexing and integrating diffraction patterns, scaling and merging intensities, simulating patterns, calculating figures of merit for the data and visualising …

In Helmholtz Imaging CONNECT
➤Applications: 1 ➤Facilities: 3 ➤Centers: 1 ➤Instruments: 1 ➤Labs: 1 ➤Modalities: 1 ➤Experts: 2

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