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DR. Oliver Lechtenfeld

Head of research group BioGeoOmics
Department Analytik / Analytical Chemistry
ProVIS - Centre for Chemical Microscopy
Helmholtz Centre for Environmental Research GmbH - UFZ

My current research focuses on applications of ultra-high resolution mass spectrometry (FT-ICR MS) in environmental, biological and biogeochemical context.
My main research topic is the rapid and ultra-sensitive detection of molecules in complex natural mixtures like natural organic matter (NOM), metabolomics and petroleomics. In addition to analytical method development I also utilize chemoinformatics-aided data evaluation techniques.
Currently, I work on the development and application of stable isotope labelling methods. In combination with the high specificity and sensitivity of the FT-ICR MS this allows compound-specific stable isotope analysis (CSSIA) to be implemented in metabolomics and biogeochemical research.
Besides identification of molecules from complex mixtures, also the spatial localization of molecules (chemicals, biological metabolites) in solid samples, e.g. in plant tissues or structured environmental systems (like soils, sediments), is a major research focus. Here, I use (matrix-assisted) laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to unravel lateral molecule distributions.


Publications

Multi-Class Cancer Subtyping in Salivary Gland Carcinomas with MALDI Imaging and Deep Learning

Pertzborn D, Arolt C, Ernst G, Lechtenfeld O, Kaesler J, Pelzel D, Guntinas-Lichius O, von Eggeling F, Hoffmann F - Cancers - 2022


Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil

Halbach K, Aulhorn S, Lechtenfeld O, Lecluse M, Leippe S, Reemtsma T, Seiwert B, Wagner S, König J, Luckenbach T - Chemical Research in Toxicology - 2022


Direct Imaging of Plant Metabolites in the Rhizosphere Using Laser Desorption Ionization Ultra-High Resolution Mass Spectrometry

Lohse M, Haag R, Lippold E, Vetterlein D, Reemtsma T, Lechtenfeld O - Frontiers in Plant Science - 2021


Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses

Muniz M, Halbach K, Alves Araruna I, Martins R, Seiwert B, Lechtenfeld O, Reemtsma T, Farias D - Environmental Pollution - 2021



Send mail to Oliver Lechtenfeld (oliver.lechtenfeld@ufz.de)

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