Grating interferometry
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Wikipedia contributors. "Grating-coupled interferometry." Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, Aug. 22, 2023.
Grating-coupled interferometry
Grating-coupled interferometry (GCI) is a biophysical characterization method mainly used in biochemistry and drug discovery for label-free analysis of molecular interactions. Similar to other optical methods such as surface plasmon resonance (SPR) or bio-layer interferometry (BLI), it is based on measuring refractive index changes within an evanescent field near a sensor surface. After immobilizing a target to the sensor surface, analyte molecules in solution which bind to that target cause a small increase in local refractive index. By monitoring these refractive changes over time characteristics such as kinetic rates and affinity constants of the analyte-target binding, or analyte concentrations, can be determined.
Read more about 'Grating-coupled interferometry' at: WikipediaWikipedia contributors. "Grating-coupled interferometry." Wikipedia, The Free Encyclopedia. Wikipedia, The Free Encyclopedia, Aug. 22, 2023.
Grating interferometry in Helmholtz Imaging CONNECT:
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